JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS This respected publication brings critical evaluation and discussion to pharmacologic and therapeutic advances in the treatment in cardiovascular disease. Four times a year, the Journal of Cardiovascular Pharmacology and Therapeutics provides a forum to examine controversies, highlight emerging issues, and share appropriate therapeutic options. Meets your need for the most current information! Every issue brings you a stimulating combination of reports of clinical trials and experimental studies. You'll also find reviews, therapeutic commentaries, point/counterpoint discussions, clinical case discussions, and hypotheses of factors associated with cardiovascular therapeutics. Journal of Cardiovascular Pharmacology and Therapeutics See for yourself how the can benefit your practice-send now to try your first issue without risk or obligation.

Here's a sampling of the coverage you can expect to receive... EDITORIAL PAGE EDITORIAL COMMENT Initial Antiarrhythmic Drug Therapy During Resuscitation from Sudden Cardiac Death: A Time for a Fundamental Change in Strategy? Bramah N. Singh REVIEW Pharmacological Management of Atrial Fibrillation: An Update Stefan H. Hohnloser, Yi-Gang Li, Birgit Bender, and Gerian Groenfeld COMMENTON CLINICAL TRIALS The Importance of Considering Trial Design When Interpreting Clinical Trial Results James A. Reiffel CLINICAL INVESTIGATIONS Efficacy of Atorvastatin Compared With Simvastatin in Patients With Hypercholesterolernia Michael Farnier, Jean-Jacques Portal, and Pascal Maigret

Acute Renal Failure After Cardiopulmonary Bypass: A Possible Association With Drugs of the Fibrate Group Kamel M. Sharobeem, Brendan P. Madden, Russell Millner, Lindsey M. Rolfe, Carol A. Seymour, and John Parker EXPERIMENTAL INVEISTIGIATIONS A New Model of Ventricular Plication: A Suturing Technique to Decrease Left Ventricular Dimensions, Improve Contractility, and Attenuate Ventricular Remodeling After Myocardial Infarction in the Rat Heart Ernst R. Schwarz, Mark T Speakman, and Robert A. Kloner Beneficial Effects of Vitamin E Treatment in Acute Myocardial Infarction Rajat Sethi, Nobuakira Takeda, Makoto Nagano, and Naranjan S. Dhalla Cardiovascular Dysfunction in Hypercholesterolemia Associated With Enhanced Formation of AT1-Receptor and of Eicosanoids Michael Schwemmer, Olaf Sommer, Reinhold Koeckerbauer, and Ebehand Bassenge